Trends in performance on neuropsychological tests for asymptomatic persons with
  
   Lead Investigator:    Charlie Mock
   Institution      :    NACC
   E-Mail           :    cmock@uw.edu
   Proposal ID      :    291


   Publications:


1  Monsell SE, Mock C , Hassenstab J, Roe CM, Cairns NJ, Morris JC,  Kukull WK
   Neuropsychological changes in asymptomatic persons with Alzheimer's disease neuropathology
   Journal Article  Neurology,83:434-440,2014,PMC4132573

   PUBLISHED



2  Monsell SE , Hassenstab J,  Mock C , Roe CM, Cairns NJ, Morris JC,  Kukull WA
   Neuropsychological markers of cognitive decline in persons with Alzheimer's disease neuropathology
   Abstract  Alzheimers Dement,11(7):240-241,2015,

   PUBLISHED



3  Hassenstab J,  Monsell SE, Mock C , Roe CM, Cairns NJ, Morris JC,  Kukull W
   Neuropsychological Markers of Cognitive Decline in Persons With Alzheimer Disease Neuropathology
   Journal Article  J Neuropathol Exp Neurol,74:1086-1092,2015,PMC4610245

   PUBLISHED





   Proposal Description:
   In a previous analysis of NACC data we identified demographic and clinical features that were associated with expression of symptoms in the presence of Alzheimer???s disease neuropathologic changes. We defined asymptomatic subjects as having a Clinical Dementia Rating (CDR) global score =0 and symptomatic subjects as having a CDR>0. We now wish to compare the asymptomatic group to other cognitive-normally subjects without AD pathology in order to determine (1) whether persons with AD neuropathologic change and CDR global score of 0 have more subtle changes that are detectable by neuropsychological tests, (2)  the trajectory of these potential changes over time, and (3) the clinical and neuropathologic features affecting these changes.